variant

Study: Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant. Image Credit: NIAID

Nirmatrelvir, Molnupiravir, and Remdesivir hold-up against SARS-CoV-2 Omicron variant in vitro

In a recent study posted to the bioRxiv* preprint server, researchers test three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals authorized for emergency use by the United States Food and Drug Administration (FDA) for their in vitro potency against several SARS-CoV-2 variants, including the currently dominant Omicron train. Study: Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent …

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Study: Evidence of increased Cathepsin B/L and decreased TMPRSS2 usage for cell entry by the SARS-CoV-2 Omicron variant. Image Credit: MedMoMedia/Shutterstock

Study supports that Omicron variant has shifted to better usage of Cathepsin B/L entry pathway

The evolution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, has led to the emergence of many new variants. These variants are different from the original SARS-CoV-2 strain, which was first reported in China in 2019. Some of the emerged variants have been classified …

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Vaccines alone are ineffective against the widely circulating Omicron variant

Vaccines alone are ineffective against the widely circulating Omicron variant

Millions of people around the world have received two shots of Sinovac, a Chinese-manufactured inactive vaccine that is used in 48 countries to help reduce transmission rates of COVID-19. However, those vaccinations alone are of no help against the widely circulating Omicron variant, show a new study by researchers at Yale and the Dominican Republic. …

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Vaccine used in much of the world no match for Omicron variant

Vaccine used in much of the world no match for Omicron variant

Credit: Pixabay/CC0 Public Domain Millions of people around the world have received two shots of Sinovac, a Chinese-manufactured inactive vaccine that is used in 48 countries to help reduce transmission rates of COVID-19. However, those vaccinations alone are of no help against the widely circulating Omicron variant, show a new study by researchers at Yale …

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Omicron variant is more transmissible but vaccines are still effective

Omicron variant is more transmissible but vaccines are still effective

Credit: University of Montreal Last summer, a team of researchers at Université de Montréal succeeded in modeling the spike protein of SARS-CoV-2, the virus responsible for COVID-19, and simulating more than 17,000 possible mutations on a computer. Using their computer-generated model, the researchers have now determined that the Omicron variant is more transmissible but not …

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Study: Assessing the clinical severity of the Omicron variant in the Western Cape Province, South Africa, using the diagnostic PCR proxy marker of RdRp target delay to distinguish between Omicron and Delta infections – a survival analysis. Image Credit: Fit Ztudio/Shutterstock

Analyzing disease severity of SARS-CoV-2 Omicron variant using RNA dependent RNA polymerase target delay

In a recent study posted to the medRxiv* pre-print server, a team of researchers compared the severity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant to the Delta variant using the polymerase chain reaction (PCR) proxy marker of RNA dependent RNA polymerase (RdRp) target delay. Study: Assessing the clinical severity of …

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Study: Structural and functional impact by SARS-CoV-2 Omicron spike mutations. Image Credit: MattLphotography/Shutterstock

Omicron variant spike protein shows significantly weaker membrane fusion activity than other variants

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has shown significantly higher transmission rates than other variants, despite lower rates of severe disease. Researchers from Harvard Medical School are investigating the membrane fusion activity and structure of the spike protein of this variant in order to better understand these differences. Study: Structural …

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COVID variant siblings show different levels of virulence

COVID variant siblings show different levels of virulence

Credit: Pixabay/CC0 Public Domain As the world enters a third year of pandemic-related uncertainties, one thing does seem certain: The SARS-CoV-2 virus mutates and keeps us on our toes. New research from the lab of Gary Whittaker, professor of virology in the Department of Microbiology and Immunology in the Cornell University College of Veterinary Medicine, …

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UK virus hunting labs seek to bolster global variant network

UK virus hunting labs seek to bolster global variant network

Research assistant Emily checks a flow cell before putting it into the sequencer at the Wellcome Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, England, Friday, on Jan. 7, 2022. By sequencing as many positive cases as possible, researchers hope to identify variants of concern as quickly as possible, then track their spread to provide early warnings …

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