treatment

FoxOs are unique master regulators of cellular inflammatory and redox responses. The FoxO family of transcription factors modulates transcriptional expression of numerous genes that are part of the host inflammation mechanism, including several interleukins, chemokines and cytokines. FoxOs also play pivotal roles in the redox homeostasis and immune response. The loss of this intricate regulatory mode of FoxOs may, thus, lead to inefficient oxidative stress response, abnormal immune cell activation and a state of exacerbated inflammation, reminiscent of a ‘cytokine storm’.

Forkhead box O’s potential therapeutic use in the treatment of COVID-19

In a recent study, Indian researchers from the Department of Biochemistry, University of Delhi, reviewed a possible vital coalition of FoxOs – the Forkhead Box O subfamily of protein transcription factors, with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the etiological agent of COVID-19 (coronavirus disease). This review work is posted in the journal, Open …

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Promising ovarian cancer treatment proves effective and efficient

Promising ovarian cancer treatment proves effective and efficient

Bioluminescence images overlayed with pictures of representative mice implanted intraperitoneally with luciferase-positive ovarian cancer cells (SKOV3) before and after treatment with Pb-214-TCMC-trastuzumab. Credit: Abdullah Metebi, PhD Student at the Institute for Quantitative Health Science and Engineering, Michigan State University. Preclinical trials of a new radiopharmaceutical to treat ovarian cancer have produced successful results, dramatically limiting …

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Study sheds light on treatment options for devastating childhood brain cancer

Study sheds light on treatment options for devastating childhood brain cancer

A new study led by Washington University School of Medicine in St. Louis provides new guidance on the treatment of medulloblastoma, a pediatric brain cancer. Some aspects of radiation therapy may be reduced while still providing effective treatment. Shown is a proton therapy plan for a patient with medulloblastoma. An extra “boost” radiation dose to …

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Team develops potential treatment for life-threatening microbial inflammation

Team develops potential treatment for life-threatening microbial inflammation

From left, Taylor Smith, MS, Jacek Hawiger, MD, PhD, Jozef Zienkiewicz, PhD, and Yan Liu, MD, and colleagues developed a peptide that may protect against life-threatening microbial inflammation with underlying metabolic syndrome. Credit: Hawiger lab A cell-penetrating peptide developed by researchers at Vanderbilt University Medical Center can prevent, in an animal model, the often-fatal septic …

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New treatment demonstrated for people with vaccine clots

New treatment demonstrated for people with vaccine clots

Angela Huynh, PhD working in the McMaster Platelet Immunology Laboratory. Credit: McMaster University A new lifesaving treatment for people suffering from vaccine-related blood clots has been demonstrated by scientists at McMaster University. Researchers at the McMaster Platelet Immunology Laboratory (MPIL) are recommending two treatments, a combination of anti-clotting drugs with high doses of intravenous immunoglobulin, …

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Disparities in treatment persist for people with headache

Disparities in treatment persist for people with headache

Credit: Pixabay/CC0 Public Domain Disparities exist in the treatment of people with headache disorders because of race and ethnicity, socioeconomic status and geography, according to a review article published in the June 9, 2021, online issue of Neurology. The article, developed by 16 headache experts, reviews the existing research on headache and health care disparities …

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A targeted treatment for IgA nephropathy at last?

A targeted treatment for IgA nephropathy at last?

This image shows a cross section of a kidney. Credit: Holly Fischer/Wikipedia IgA nephropathy (IgAN) is a chronic kidney disease occurring in young adults and is one of the most common reasons for kidney transplantation in this age group. IgAN is the most common form of glomerulonephritis (GN), i.e., immunologically induced inflammation of the renal …

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Gene therapy may be a safe and effective single-dose treatment for soft bone disease

Gene therapy may be a safe and effective single-dose treatment for soft bone disease

A preclinical study led by scientists at Sanford Burnham Prebys has established that AAV8-TNAP-D10–a gene therapy that replaces a key enzyme found in bone–may be a safe and effective single-dose treatment for hypophosphatasia (HPP). The study, published in the Journal of Bone and Mineral Research and performed in a murine model of the disease, further …

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FDA grants accelerated approval for first-of-its-kind Alzheimer's treatment

FDA grants accelerated approval for first-of-its-kind Alzheimer’s treatment

Today, the U.S. Food and Drug Administration approved Aduhelm (aducanumab) for the treatment of Alzheimer’s, a debilitating disease affecting 6.2 million Americans. Aduhelm was approved using the accelerated approval pathway, which can be used for a drug for a serious or life-threatening illness that provides a meaningful therapeutic advantage over existing treatments. Accelerated approval can …

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Shorter treatment regimen found to be effective for treating TB

Shorter treatment regimen found to be effective for treating TB

Tuberculosis (TB) is a deadly infection that occurs in every part of the world. The standard treatment for TB, a six-month multidrug regimen, has not changed in more than 40 years. Patients can find it difficult to complete the lengthy regimen, making it more likely that treatment resistance will develop. A research team led by …

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