therapy

Study: Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target. Image Credit: Dana.S/ Shutterstock

Pinning down Pin1: Potential COVID-19 therapy

In their recent study published in Nature Scientific Reports, scientists from Japan have demonstrated that Prolyl isomerase Pin1 is one of the key cellular molecules necessary for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) propagation. Study: Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target. Image …

Pinning down Pin1: Potential COVID-19 therapy Read More »

Systematic review focuses on women's health associated with menopausal hormone therapy

Systematic review focuses on women’s health associated with menopausal hormone therapy

Treatment with estrogen in menopause is both good and bad for women’s health. The picture is complex and the scientific evidence sometimes scanty or only moderately solid, a study shows. University of Gothenburg researchers took part. The study, now published in the journal PLOS Medicine, is a systematic review and critical analysis of previous research …

Systematic review focuses on women’s health associated with menopausal hormone therapy Read More »

Ribociclib added to endocrine therapy extends survival in postmenopausal patients with metastatic breast cancer

A study led by researchers from The University of Texas MD Anderson Cancer Center showed a significant overall survival benefit with ribociclib plus endocrine therapy for postmenopausal patients with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer. This is the first demonstration of a survival advantage with a front-line CDK4/6 …

Ribociclib added to endocrine therapy extends survival in postmenopausal patients with metastatic breast cancer Read More »

Novel combination therapy approach to keep leukemia at bay

Novel combination therapy approach to keep leukemia at bay

In chronic leukemias, blocking the overactive kinase JAK2 by a targeted therapy approach is only mitigating the patients’ symptoms, but cannot truly change the course of the disease. A study by the University of Basel has shown that it may be possible to improve the therapeutic effects by additionally inhibiting a specific signaling pathway. The …

Novel combination therapy approach to keep leukemia at bay Read More »

A review of mesenchymal stem cell therapy for severe COVID-19

A review of mesenchymal stem cell therapy for severe COVID-19

Severe coronavirus disease 2019 (COVID-19) is associated with dysregulation of the host’s innate and adaptive immune response and can result in excessive inflammation and organ failure. Besides generic antiviral treatments and oxygen supplementation, certain forms of immunomodulatory treatment, such as antibody therapy, have proven somewhat effective in treating severe COVID-19. However, the side effects of …

A review of mesenchymal stem cell therapy for severe COVID-19 Read More »

A new gene-delivery vehicle could make gene therapy for muscle diseases safer and more effective

A new gene-delivery vehicle could make gene therapy for muscle diseases safer and more effective

Credit: CC0 Public Domain Genetic muscle diseases lead to progressive muscle wasting and often early death, with few treatment options and no cure. Some gene therapies that use a harmless virus to deliver a functioning copy of a disease-causing gene to cells have shown promise in clinical trials for a subset of muscular dystrophies, but …

A new gene-delivery vehicle could make gene therapy for muscle diseases safer and more effective Read More »

One-day online therapy session can help treat postpartum depression

One-day online therapy session can help treat postpartum depression

A one-day online therapy session can help treat postpartum depression (PPD), says a study led by McMaster University scientists. Researchers ran the online workshops for 403 mothers with PPD between April and October last year, at the height of the pandemic. The research findings were published in JAMA Psychiatry. Lead author Ryan Van Lieshout said …

One-day online therapy session can help treat postpartum depression Read More »

Combo therapy cuts risk of heart attacks and strokes in half

Combo therapy cuts risk of heart attacks and strokes in half

Credit: CC0 Public Domain A combination therapy of aspirin, statins and at least two blood pressure medications given in fixed doses can slash the risk of fatal cardiovascular disease (CVD) by more than half, says an international study led by Hamilton researchers. The fixed-dose combination (FDC) therapies were examined both with and without aspirin versus …

Combo therapy cuts risk of heart attacks and strokes in half Read More »

ESC guidelines on cardiac pacing and cardiac resynchronization therapy launched today

ESC guidelines on cardiac pacing and cardiac resynchronization therapy launched today

Credit: CC0 Public Domain The European Society of Cardiology (ESC) Guidelines on cardiac pacing and cardiac resynchronization therapy (CRT) are published online today in European Heart Journal. The use of pacemakers continues to grow as populations worldwide are living longer. It is estimated that around one million devices are implanted globally every year. Pacemakers are …

ESC guidelines on cardiac pacing and cardiac resynchronization therapy launched today Read More »

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, which has expanded its focus to include evaluating outpatient treatment for COVID-19, today announced positive data for the monoclonal antibody combination therapy BRII-196/BRII-198 from the ACTIV-2 study of Outpatient Monoclonal Antibodies and Other Therapies. In an interim analysis of the phase 3 evaluation …

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study Read More »