therapy

Nanoparticle therapy shows promise at preventing fatal newborn lung disease

Nanoparticle therapy shows promise at preventing fatal newborn lung disease

Left: normal mouse lung tissue showing a healthy density of blood vessels. Middle: example of abnormal, diseased tissue with reduced STAT3 activation. Right: tissue from a treated mouse. Green depicts blood vessels; Red, shows activated STAT3. Credit: Cincinnati Children’s A new therapy offers help for a disease so rare and complex that its acronym is …

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Enterprise Therapeutics doses first subjects in Phase I trial for novel cystic fibrosis therapy ETD001

Enterprise Therapeutics doses first subjects in Phase I trial for novel cystic fibrosis therapy ETD001

Jun 14 2021 Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve the lives of patients suffering from respiratory disease, today announced it has successfully dosed the first subjects in a Phase 1 trial for its novel inhaled cystic fibrosis (CF) therapy, ETD001. The first-in-man safety …

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New research finds sense of smell and pneumonia linked

Study highlights need to monitor oxygen therapy in children with pneumonia

Credit: Unsplash/CC0 Public Domain Oxygen therapy can save the lives of children with pneumonia, but careful monitoring is needed to reduce harm, avoid over-reliance and protect supply. These are among some of the key findings to emerge from a four-year-long study of children hospitalized with severe pneumonia in East Africa. Led by researchers at Imperial …

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Monoclonal antibody therapy for COVID-19 safe, effective for transplant patients

Treating transplant patients with mild to moderate cases of COVID-19 with monoclonal antibodies is safe and helps prevent serious illness, according to a Mayo Clinic study recently published in Open Forum Infectious Diseases. These results are especially important because transplant patients who are infected with COVID-19 have a higher risk of severe illness and death. …

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Nintendo Wii therapy can help improve balance in children with cerebral palsy

Nintendo Wii therapy can help improve balance in children with cerebral palsy

Therapy based on the Nintendo® Wii Balance Board can help improve balance in children with cerebral palsy, according to an analysis published in Developmental Medicine & Child Neurology. For the analysis, researchers from the University of Jaén, in Andalusia, Spain examined data from all relevant randomized controlled trial published to date. In 11 trials with …

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Gene therapy may be a safe and effective single-dose treatment for soft bone disease

Gene therapy may be a safe and effective single-dose treatment for soft bone disease

A preclinical study led by scientists at Sanford Burnham Prebys has established that AAV8-TNAP-D10–a gene therapy that replaces a key enzyme found in bone–may be a safe and effective single-dose treatment for hypophosphatasia (HPP). The study, published in the Journal of Bone and Mineral Research and performed in a murine model of the disease, further …

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New targeted therapy provides survival benefit in KRAS G12C-mutated lung cancer

New targeted therapy provides survival benefit in KRAS G12C-mutated lung cancer

Results from the Phase II cohort of the CodeBreaK 100 study showed that treatment with the KRAS G12C inhibitor sotorasib achieved a 37.1% objective response rate and 12.5 months median overall survival in previously treated patients with KRAS G12C-mutated non-small cell lung cancer (NSCLC), according to researchers from The University of Texas MD Anderson Cancer …

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Gene therapy more cost effective than current treatments for hemophilia B

Gene therapy more cost effective than current treatments for hemophilia B

Credit: CC0 Public Domain A St. Jude Children’s Research Hospital analysis found a major gap between the cost to manufacture and distribute hemophilia B gene therapy and the $2 million-plus price reportedly under consideration for hemophilia gene therapy now in development. The study appeared online in the journal Blood. It is the first to report …

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Lower mortality rate for men at high risk for death from prostate cancer who received postoperative radiation therapy

Lower mortality rate for men at high risk for death from prostate cancer who received postoperative radiation therapy

Credit: CC0 Public Domain In a large, international retrospective study, men at high risk for death from prostate cancer had a significant reduction in all-cause mortality if treated with radiation shortly after surgery. Prostate cancer is one of the most common forms of cancer among men, and about 1-in-8 of them will be diagnosed with …

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