therapy

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

Preliminary findings from Penn Medicine in an ongoing first-in-human clinical trial examining the safety, tolerability and feasibility of chimeric antigen receptor macrophage (CAR-M) has helped to establish the viability of this innovative immunotherapy, which advances the trailblazing scientific discovery of CAR T cell therapy- also pioneered at Penn- for solid cancer tumors and offers a …

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Ketamine and psychological therapy helped severe alcoholics abstain for longer in trial

Ketamine and psychological therapy helped severe alcoholics abstain for longer in trial

Credit: CC0 Public Domain People with severe alcohol disorder were able to stay off alcohol for longer when they were treated with low doses of ketamine combined with psychological therapy in a clinical trial. The Ketamine for reduction of Alcohol Relapse (KARE) trial was led by the University of Exeter and funded by the Medical …

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New technology is one step closer to targeted gene therapy

New technology is one step closer to targeted gene therapy

Multiple sites of the AAV capsid are engineered to acquire brain specificity while being targeted away from the liver in mice after in vivo selection. On the left, the engineering sites on the AAV capsid and monomer are depicted in purple and green, while on the right transgene expression (shown in green) is depicted in …

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amino acid sequences

‘Moving molecule’ therapy for severe spinal cord injury

Please can you introduce yourself and tell us what inspired your recent research into the treatment of severe spinal cord injuries? I am Samuel Stupp, Professor of Chemistry, Materials Science and Engineering, Medicine, and Biomedical Engineering at Northwestern University. I am also the director of the Simpson Querrey Institute for BioNanotechnology at Northwestern University. I …

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Targeting the brain should be the focus of ALS therapy, not just spinal cord

Targeting the brain should be the focus of ALS therapy, not just spinal cord

The brain is indeed a target for treating ALS (amyotrophic lateral sclerosis), Northwestern Medicine scientists have discovered. This flips a long-standing belief that the disease starts in the spinal motor neurons and any therapy would need to target the spine as the key focus. A new Northwestern study shows the degeneration of brain motor neurons …

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Digital therapy for prenatal insomnia may prevent postpartum depression

Digital therapy for prenatal insomnia may prevent postpartum depression

Credit: Unsplash/CC0 Public Domain A digital version of cognitive behavioral therapy, or dCBT, that previously had been shown to reduce insomnia during pregnancy may also prevent postpartum depression and reduce insomnia and anxiety in women up to six months after they give birth, according to a new study by researchers at UC San Francisco. The …

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Distinct gut bacterial profile highly responsive to IBS dietary therapy identified

Distinct gut bacterial profile highly responsive to IBS dietary therapy identified

Credit: CC0 Public Domain People who respond well to the recommended dietary therapy of restricting intake of fermentable carbs for irritable bowel syndrome, or IBS for short, have an abundance of particular types of bacteria in their gut, reveals research published online in the journal Gut. The finding opens up the potential for new treatments …

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Novel gene therapy for hemophilia A leads to sustained expression of clotting factor and reduced bleeding events

Novel gene therapy for hemophilia A leads to sustained expression of clotting factor and reduced bleeding events

Lindsey A. George, MD, lead study author and attending hematologist at Children’s Hospital of Philadelphia. Credit: Children’s Hospital of Philadelphia A novel gene therapy for hemophilia A led to sustained expression of the clotting factor those patients lack, resulting in a reduction—or in some cases complete elimination—of painful and potentially life-threatening bleeding events, according to …

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Giving immunotherapy before targeted therapy improves survival in advanced melanoma

Giving immunotherapy before targeted therapy improves survival in advanced melanoma

Melanoma in skin biopsy with H&E stain — this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0 More people with advanced melanoma survive for two years or more when they receive a combination of two immunotherapy drugs given before a combination of two targeted therapies, if needed, compared to people who start treatment …

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Zika virus-specific therapy protects the fetal mouse brain

Zika virus-specific therapy protects the fetal mouse brain

Transmission electron microscope image of negative-stained, Fortaleza-strain Zika virus (red), isolated from a microcephaly case in Brazil. The virus is associated with cellular membranes in the center. Credit: NIAID A gene-silencing therapy protected against Zika virus transmission from pregnant mice to the mouse fetuses, finds a study published November 10th in the journal Molecular Therapy. …

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