Scientists

Scientists develop artificial intelligence method to predict anti-cancer immunity

Scientists develop artificial intelligence method to predict anti-cancer immunity

Activation of T cell immune response with the interaction of MHC-II (red) with the T cell receptor (TCR, blue), and also CD4 (light blue). CD4 and MHC-II are proteins expressed by T cells and antigen-presenting cells, respectively, to aid the recognition of antigens by TCRs. Credit: UT Southwestern Medical Center Researchers and data scientists at …

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Scientists characterize new genetic variants that cause nonsyndromic neurodevelopmental disorder

Scientists characterize new genetic variants that cause nonsyndromic neurodevelopmental disorder

Northwestern Medicine scientists have characterized several variants of the gene GRIK2 that cause nonsyndromic neurodevelopmental disorder (NDD), according to a study published in the American Journal of Human Genetics. These findings add two new genetic variants to a growing list of glutamate receptor mutations that can cause neurodevelopmental disorders, according to Geoffrey Swanson, PhD, professor …

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Study: Aging-related cell type-specific pathophysiologic immune responses that exacerbate disease severity in aged COVID-19 patients. Image Credit: Ann Kosolapova/ Shutterstock

Scientists identify potential therapeutic targets to alleviate severe COVID-19 in aged patients

Coronavirus disease 2019 (COVID-19) disproportionately affects patients 65 years and older. Age-related impaired host immunity has been implicated for severe outcomes of COVID-19. Researchers have performed a study on large data set to understand better the molecular basis of vulnerability in aged COVID-19 patients. They observed certain age-linked immunoinflammatory factors associated with severe COVID-19 and …

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Scientists examine kids’ unique immune systems as more fall victim to covid

Scientists examine kids’ unique immune systems as more fall victim to covid

Eighteen months into the covid-19 pandemic, with the delta variant fueling a massive resurgence of disease, many hospitals are hitting a heartbreaking new low. They’re now losing babies to the coronavirus. The first reported covid-related death of a newborn occurred in Orange County, Florida, and an infant has died in Mississippi. Merced County in California …

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Scientists discover new cell type in human skin that contributes to inflammatory skin diseases

Scientists discover new cell type in human skin that contributes to inflammatory skin diseases

A team of international scientists and clinical experts have unraveled a new cell type in human skin that contributes to inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis (PSO). Their study findings were published in the Journal of Experimental Medicine in September 2021. The team hails from A*STAR’s Singapore Immunology Network (SIgN), in …

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Scientists identify new approach to overcome resistance to cancer immunotherapy

Scientists identify new approach to overcome resistance to cancer immunotherapy

Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer. The activation of checkpoint proteins on the surfaces of immune cells helps regulate the immune response by …

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Scientists identify a possible “Achilles’ heel” in the frustration of amyloid beta peptides

Scientists identify a possible “Achilles’ heel” in the frustration of amyloid beta peptides

Progress on treating Alzheimer’s disease has been frustratingly slow. A group of scientists in Houston suggest frustration at a very small scale may lead to a new path toward treatment. Researchers at the University of Houston (UH) and at Rice University, associated with the Rice-based Center for Theoretical Biological Physics (CTBP), found through experiments and …

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Scientists create a novel cell model for understanding human development

Scientists create a novel cell model for understanding human development

Sep 9 2021 The earliest moments of human development—between the time of fertilization and when the embryo implants in the womb—have remained opaque to scientists. Cells in the earliest stages of human development have the ability to generate all tissues in the body and the placenta. Unfortunately, issues such as miscarriage and birth defects can …

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Scientists grow miniature brains that mimic the major pathological features of Parkinson's disease

Scientists grow miniature brains that mimic the major pathological features of Parkinson’s disease

Small pea-sized human midbrain-like organoids—which are essentially three-dimensional, multicellular, in vitro tissue constructs that mimic the human midbrain—are grown from human stem cells to enable scientists to study how the human brain develops and communicates. Credit: Associate Professor Hyunsoo Shawn Je, Duke-NUS Medical School Tiny brains-in-a-dish that mimic the major pathological features of Parkinson’s disease …

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S.Africa scientists monitoring new coronavirus variant

S.Africa scientists monitoring new coronavirus variant

Credit: Pixabay/CC0 Public Domain Scientists in South Africa are monitoring a new coronavirus variant with an unusually high mutation rate, and whose frequency has gradually increased in recent months, the National Institute for Communicable Diseases said Monday. The variant, known as C.1.2., was flagged last week by the KwaZulu-Natal Research and Innovation and Sequencing Platform …

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