SARSCoV2

Study: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. Image Credit: NIAID

An alternative mouse model of SARS-CoV-2 infection

The coronavirus disease-2019 (COVID-19) pandemic, caused by the rapid outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has massively affected the global healthcare system and economy. The virus has been characterized to be highly transmissible and virulent. To date, it has infected around 330 million people and claimed more than 5.54 million lives worldwide. …

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Study: Ozone for SARS-CoV-2 inactivation on surfaces and in liquid cell culture media. Image Credit: vered sh / Shutterstock

Gaseous ozone is effective for SARS-CoV-2 disinfection

In their recent study published in the Journal of Hazardous Materials, researchers from the United Kingdom have found that ozone as a disinfectant is effective for the inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in liquid cell culture media as well as adhered on surfaces. SARS-CoV-2 efficiently transmits via inhalation of contaminated aerosols or …

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Study: SARS-CoV-2 Triggers Complement Activation Through Interactions With Heparan Sulfate. Image Credit: CROCOTHERY / Shutterstock.com

SARS-CoV-2 interacts with heparan sulfate to activate the alternative pathway

The current coronavirus disease 2019 (COVID-19) pandemic, which is due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused over 5.5 million casualties to date. Despite intensive research into the virus in order to develop vaccines and therapeutic drugs, much remains to be known about the mechanism by how SARS-CoV-2 infection can lead …

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Study: Systemic infection of SARS-CoV-2 in free ranging Leopard (Panthera pardus fusca) in India. Image Credit: Ondrej Chvatal/Shutterstock

Exploring the systemic infection of SARS-CoV-2 in a wild leopard in India

Recently, natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are increasingly being reported in various domesticated and captive wild species, while both in-silico and experimental infections of SARS-CoV-2 have uncovered immunogenicity and pathogenesis of the virus in numerous species. Such infections are considered spillover infections and evidence of large-scale veterinary infections are lacking. A …

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Study: SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike-ACE2 receptor interaction. Image Credit: MattLphotography/Shutterstock

Study shows SARS-CoV-2 prompts NLRP3 inflammasome activation through spike-ACE2 receptor interaction

Neuroinflammation – a hallmark of neurodegenerative diseases, can be driven by a variety of triggers within the central nervous system (CNS). Such stimuli may include – pathogens, injury, toxic metabolites, and protein aggregates. Study: SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike-ACE2 receptor interaction. Image Credit: MattLphotography/Shutterstock Among pathogens, viruses may …

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Study: SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection. Image Credit: Imilian/Shutterstock

Study demonstrates that intra-host SARS-CoV-2 variants with reduced infectivity are developed during infection

The rapid development and rollout of vaccines on a messenger ribonucleic acid (mRNA) platform, encoding the spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent behind the ongoing coronavirus disease 2019 (COVID-19) pandemic, was heralded as a great step towards speeding up the end of the pandemic. Study: …

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Study: SARS-CoV-2 BNT162b2 vaccine-induced humoral response and reactogenicity in individuals with prior COVID-19 disease. Image Credit: Irina Shatilova/Shutterstock

Study investigates whether immune responses to BNT162b2 vaccine differ in subjects with and without prior SARS-CoV-2 infection

The rollout of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was expected to achieve population-level immunity preventing reinfection, and thus an eventual end to the pandemic of coronavirus disease 2019 (COVID-19). However, the emergence of variants that demonstrate resistance to neutralization by antibodies to the ancestral virus or earlier variants threatens …

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Image Credit: Erni / Shutterstock

Monitoring rodents for SARS-CoV-2 and other coronaviruses, Hong Kong

A novel coronavirus, namely, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was first reported in Wuhan, China, in late 2019. The subsequent rapid global outbreak of SARS-CoV-2 was declared a pandemic, by the World Health Organization (WHO), in March 2020. This pandemic is popularly known as coronavirus disease 2019 (COVID-19). Study: Surveillance of Rodent Pests for SARS-CoV-2 …

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Study: Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Image Credit: Warah38 / Shutterstock

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

Ever since the emergence and rapid spread of severe acute respiratory syndrome coronavirus (SARS-CoV) in southern China in 2002, scientists have considered coronaviruses to be a potential threat to humans. Another member of the coronavirus family, namely, Middle East respiratory syndrome coronavirus (MERS-CoV), showed high transmission and mortality rate; however, it did not spread across …

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Study: Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein. Image Credit: Dmytro Tyshchenko / Shutterstock

Cannabidiol may improve innate immune response against SARS-CoV-2

A recent study shows evidence that cannabidiol, an important active ingredient in the Cannabis sativa plant, can augment the antiviral innate immune response and prophylactically prime the innate antiviral response of cells – enabling in turn improved response against viruses such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The research paper is currently …

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