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Cracking the mystery of a rare bleeding disorder—and pursuing ‘off-the-shelf’ drugs to treat it

Credit: CC0 Public Domain Consider for a moment that your life is dominated by spontaneous nosebleeds, chronic stomach hemorrhaging, persistent anemia and a complex constellation of other manifestations, some potentially life-threatening. These symptoms characterize a rare genetic condition known as hereditary hemorrhagic telangiectasia, or HHT. The disorder disrupts the normal …

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