large

Women who suffer emergent large vessel occlusion strokes less likely to receive timely care

Women who suffer emergent large vessel occlusion strokes less likely to receive timely care

Women are less likely than men to receive timely care for strokes caused by blockages in large vessels, known as emergent large vessel occlusion (ELVO), according to researchers with The University of Texas Health Science Center at Houston (UTHealth). The study, “Women with Large Vessel Occlusion Acute Ischemic Stroke Are Less Likely to Be Routed …

Women who suffer emergent large vessel occlusion strokes less likely to receive timely care Read More »

Overview of currently available methods to produce stable and homogeneous large nanodiscs. (A) Sortase based MSP circularization strategy. Sortase cleaves between the Gly and Thr of the LPXTG motif at the C-teminus of MSP and catalyzes the formation of an amide bond with the N-terminal Gly resulting in a circular MSP which can be used to assemble nanodiscs of sizes ranging from 9 to 50 nm. (B) Split intein-based strategy for circularization of MSP in vivo using Npu DnaE split-intein. MSP fusion results in nanodiscs as big as 26 nm. (C) Outline of DNA-corralled nanodisc protocol. Small nanodiscs functionalized with oligos bind to specified sites on the DNA origami resulting in a small nanodisc-decorated barrel. Addition of detergents and lipids, followed by removal of detergents using dialysis, leads to reconstitution of large nanodiscs within DNA barrel.

Large nanodiscs simulate viral entry into host cells

Membrane proteins are heavily involved in a variety of cellular processes such as signal transduction, membrane translocation, cell adhesion, and many more, and therefore are of great interest within the field of drug design. The structure of relevant membrane proteins is sometimes mimicked during research using detergent micelles, which are capable of entrapping and extracting …

Large nanodiscs simulate viral entry into host cells Read More »

Regular monitoring may be only way to prevent large COVID-19 outbreaks in schools

Regular monitoring may be only way to prevent large COVID-19 outbreaks in schools

Depiction of classroom transmission. The classroom has five groups of students who are considered close contacts. The index case (dark red) attends a class in which all other students are susceptible. The index case may infect some other students directly (medium red), and they may go on to infect others (pale red). Transmission can occur …

Regular monitoring may be only way to prevent large COVID-19 outbreaks in schools Read More »

Haiti fights large COVID-19 spike as it awaits vaccines

Haiti fights large COVID-19 spike as it awaits vaccines

A hospital emplyee wearing protective gear as a precaution against the spread of the new coronavirus, transports oxygen tanks, in Port-au-Prince, Haiti, Saturday, June 5, 2021. Haiti defied predictions and perplexed health officials by avoiding a COVID-19 crisis for more than a year, but the country of more than 11 million people that has not …

Haiti fights large COVID-19 spike as it awaits vaccines Read More »

Antibiotics no help for mysterious lung-scarring disease, large trial finds

Antibiotics no help for mysterious lung-scarring disease, large trial finds

A chest radiograph of a patient with Idiopathic Pulmonary Fibrosis (IPF). Credit: Wikipedia/CC BY-SA 3.0 Doctors have hoped that antibiotics could benefit patients with chronic lung diseases, but a new study has found no benefit for patients with life-threatening idiopathic pulmonary fibrosis in preventing hospitalization or death. While there were no statistical benefits for patients …

Antibiotics no help for mysterious lung-scarring disease, large trial finds Read More »

First reported cases of clots in large arteries causing stroke following COVID-19 vaccination

First reported cases of clots in large arteries causing stroke following COVID-19 vaccination

Credit: CC0 Public Domain Clots in the arteries (arterial thrombosis) are the most common cause of stroke (ischaemic stroke) and have been reported in detail for the first time in young adults who received the Oxford-AstraZeneca COVID-19 vaccine in a letter from UK stroke specialists published online in Journal of Neurology Neurosurgery & Psychiatry. While …

First reported cases of clots in large arteries causing stroke following COVID-19 vaccination Read More »

Study of airborne transmission of COVID-19 will help reopen large recreational events

Study of airborne transmission of COVID-19 will help reopen large recreational events

Credit: CC0 Public Domain A new Loughborough University-led study will create clear guidance on how to design and operate non-domestic buildings to minimize the risk of airborne transmission of COVID-19, and other viruses. The government funded AIRBODS (Airborne Infection Reduction through Building Operation and Design for SARS-CoV-2) project will help get large-scale events back up …

Study of airborne transmission of COVID-19 will help reopen large recreational events Read More »

Large NIH Clinical Trial Will Test Polyclonal Antibody Therapeutic for COVID-19. Image Credit: ktsdesign / Shutterstock

NIH to conduct large trial for COVID-19 polyclonal antibody therapies

The National Institutes of Health (NIH) in the USA are to conduct a large-scale clinical trial to evaluate a new fully-human polyclonal antibody therapy targeted at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19). Non-hospitalized people with mild or moderate cases of COVID-19 are to be enrolled at …

NIH to conduct large trial for COVID-19 polyclonal antibody therapies Read More »

Large clinical trial to study repurposed drugs to treat COVID-19 symptoms

Large clinical trial to study repurposed drugs to treat COVID-19 symptoms

Credit: CC0 Public Domain Using an ACTIV master protocol, the trial will focus on potential interventions for mild-to-moderate illness. The National Institutes of Health will fund a large, randomized, placebo controlled Phase 3 clinical trial to test several existing prescription and over-the-counter medications for people to self-administer to treat symptoms of COVID-19. Part of the …

Large clinical trial to study repurposed drugs to treat COVID-19 symptoms Read More »

Large US study suggests survival benefit for severely ill COVID-19 patients treated with ECMO

Large US study suggests survival benefit for severely ill COVID-19 patients treated with ECMO

Credit: Pixabay/CC0 Public Domain For critically ill COVID-19 patients treated with extracorporeal membrane oxygenation (ECMO), the risk of death remains high—but is much lower than suggested by initial studies, according to a report published today by Annals of Surgery. The findings support the use of ECMO as “salvage therapy” for COVID-19 patients with acute respiratory …

Large US study suggests survival benefit for severely ill COVID-19 patients treated with ECMO Read More »