Investigational

A quick, high-yield synthesis of molnupiravir, an investigational COVID antiviral pill

A quick, high-yield synthesis of molnupiravir, an investigational COVID antiviral pill

A new synthetic route could help ensure an adequate supply of molnupiravir, a promising antiviral drug for COVID-19. Credit: Merck Sharp & Dohme Corp. As SARS-CoV-2 continues to spread and mutate, it’s important to identify new treatment options. Molnupiravir is an investigational oral antiviral being developed for the treatment of COVID-19, and has been submitted …

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Investigational magnetic device shrinks glioblastoma in first-in-world human test

Investigational magnetic device shrinks glioblastoma in first-in-world human test

Device helmet with 3 oncoscillators securely attached. The oncoscillators are connected to a controller box powered by a rechargeable battery. Credit: Houston Methodist Houston Methodist Neurological Institute researchers from the department of neurosurgery shrunk a deadly glioblastoma tumor by more than a third using a helmet generating a noninvasive oscillating magnetic field that the patient …

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Investigational antipsychotic treatment offers sustained benefits for people with dementia-related psychosis

Investigational antipsychotic treatment offers sustained benefits for people with dementia-related psychosis

Evidence of the sustained benefits of an investigational antipsychotic treatment for people with dementia-related psychosis has been published. Up to half of the 45 million people worldwide who are living with Alzheimer’s disease will experience psychotic episodes, a figure that is even higher in some other forms of dementia. Psychosis is linked to a faster …

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Investigational malaria vaccine gives strong, lasting protection

Investigational malaria vaccine gives strong, lasting protection

Malaria sporozoites, the infectious form of the malaria parasite that is injected into people by mosquitoes. Credit: NIAID Two U.S. Phase 1 clinical trials of a novel candidate malaria vaccine have found that the regimen conferred unprecedentedly high levels of durable protection when volunteers were later exposed to disease-causing malaria parasites. The vaccine combines live …

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Investigational ALS drug prolongs patient survival in clinical trial

Investigational ALS drug prolongs patient survival in clinical trial Investigational ALS drug prolongs patient survival in clinical trial Credit: CC0 Public Domain An experimental medication that was recently shown to slow the progression of the neurodegenerative disease amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, has now demonstrated the potential to also prolong patient survival. …

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Investigational COVID-19 vaccine well-tolerated, generates immune response in older adults

Investigational COVID-19 vaccine well-tolerated, generates immune response in older adults

Investigational COVID-19 vaccine well-tolerated, generates immune response in older adults Investigational COVID-19 vaccine well-tolerated, generates immune response in older adults Colorized scanning electron micrograph shows SARS-CoV-2 virus particles (yellow), isolated from a patient. Credit: NIAID A Phase 1 trial of an investigational mRNA vaccine to prevent SARS-CoV-2 infection has shown that the vaccine is well-tolerated …

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Amyotrophic Lateral Sclerosis

Investigational ALS drug generates promising clinical trial results

Investigational ALS drug generates promising clinical trial results Investigational ALS drug generates promising clinical trial results An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia An experimental medication slows the progression of the neurodegenerative …

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Investigational therapy gaining reputation as promising antiviral drug to fight COVID-19

This scanning electron microscope image shows SARS-CoV-2 (yellow)—also known as 2019-nCoV, the virus that causes COVID-19—isolated from a patient, emerging from the surface of cells (blue/pink) cultured in the lab. Credit: NIAID-RML COVID-19 patients in a clinical trial at Houston Methodist Hospital are responding quickly to the antiviral drug Remdesivir. The trial’s criteria allows for …

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FDA clears investigational new drug application for Calibr’s ‘switchable’ CAR-T therapy

Calibr, the drug discovery and development division of Scripps Research, today announced that the U.S. Food and Drug Administration has given clearance to the Investigational New Drug (IND) application for Calibr’s “switchable” CAR-T cell therapy, which is being evaluated for the treatment of certain cancers, including relapsed/refractory B-cell malignancies such as non-Hodgkin lymphoma and chronic …

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First investigational drug therapy for liver disease NASH awaiting FDA approval

Arun Sanyal, Virginia Commonwealth University. Credit: Virginia Commonwealth University Patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease and a leading cause for liver transplantation in the U.S., currently lack an approved drug therapy, but this may soon change. A large Phase III clinical trial designed in collaboration with Virginia Commonwealth University is the first …

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