Tag Archives: inhibitor

Study shows protein inhibitor as potential treatment approach for common mutations found in non-Hodgkin lymphomas

Study shows protein inhibitor as potential treatment approach for common mutations found in non-Hodgkin lymphomas 2

Cancer cell during cell division. Credit: National Institutes of Health A study at The University of Texas MD Anderson Cancer Center demonstrated a potential new approach to treating two of the most common subtypes of lymphoma through manipulation of molecular programs controlled by the cAMP-response element binding protein (CREBBP). Mutations …

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    Combination of immunotherapy and VEGF inhibitor improves survival in HCC

    Combination of immunotherapy and VEGF inhibitor improves survival in HCC 4

    Credit: CC0 Public Domain Combination therapy with the PD-L1 inhibitor atezolizumab and the VEGF inhibitor bevacizumab significantly improves overall survival and progression-free survival in patients with unresectable hepatocellular carcinoma (HCC) compared to standard of care, showed results from a phase 3 study reported at the ESMO Asia 2019 Congress. “This …

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      Acute kidney injury often seen with checkpoint inhibitor use

      Acute kidney injury often seen with checkpoint inhibitor use 6

      Patients receiving checkpoint inhibitor therapy often have acute kidney injury (AKI), according to a study published online Oct. 31 in the Clinical Journal of the American Society of Nephrology. Harish Seethapathy, M.B.B.S., from Massachusetts General Hospital in Boston, and colleagues examined the frequency, severity, etiology, and predictors of AKI among …

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        Mitochondrial activity in lung tumors predicts response to drug inhibitor

        Mitochondrial activity in lung tumors predicts response to drug inhibitor 7

        Credit: CC0 Public Domain Researchers at the UCLA Jonsson Comprehensive Cancer Center and David Geffen School of Medicine at UCLA have identified a new biomarker using a noninvasive imaging method that tracks mitochondrial activity in lung tumors. The level of activity could potentially predict which individuals with lung cancer will …

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          PARP inhibitor plus chemotherapy improves progression-free survival for advanced ovarian cancer patients

          PARP inhibitor plus chemotherapy improves progression-free survival for advanced ovarian cancer patients 8

          Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that initial treatment with the PARP inhibitor veliparib in combination with chemotherapy significantly increased progression-free survival (PFS) for patients with newly diagnosed, metastatic high-grade serous ovarian cancer, according to the results of the VELIA trial. The …

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            Research discovers inhibitor to reverse toxic DUX4 effects

            Research discovers inhibitor to reverse toxic DUX4 effects 9

            Credit: CC0 Public Domain About one in 8,000 people have facioscapulohumeral muscular dystrophy, according to a 2014 study, which is relatively common in the world of genetic diseases. New University of Minnesota Medical School research identifies an inhibitor that protects cells from toxic effects associated with this disease in cells …

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