infection

Study: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. Image Credit: NIAID

An alternative mouse model of SARS-CoV-2 infection

The coronavirus disease-2019 (COVID-19) pandemic, caused by the rapid outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has massively affected the global healthcare system and economy. The virus has been characterized to be highly transmissible and virulent. To date, it has infected around 330 million people and claimed more than 5.54 million lives worldwide. …

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Study: Systemic infection of SARS-CoV-2 in free ranging Leopard (Panthera pardus fusca) in India. Image Credit: Ondrej Chvatal/Shutterstock

Exploring the systemic infection of SARS-CoV-2 in a wild leopard in India

Recently, natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are increasingly being reported in various domesticated and captive wild species, while both in-silico and experimental infections of SARS-CoV-2 have uncovered immunogenicity and pathogenesis of the virus in numerous species. Such infections are considered spillover infections and evidence of large-scale veterinary infections are lacking. A …

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Study: SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection. Image Credit: Imilian/Shutterstock

Study demonstrates that intra-host SARS-CoV-2 variants with reduced infectivity are developed during infection

The rapid development and rollout of vaccines on a messenger ribonucleic acid (mRNA) platform, encoding the spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent behind the ongoing coronavirus disease 2019 (COVID-19) pandemic, was heralded as a great step towards speeding up the end of the pandemic. Study: …

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Study: SARS-CoV-2 BNT162b2 vaccine-induced humoral response and reactogenicity in individuals with prior COVID-19 disease. Image Credit: Irina Shatilova/Shutterstock

Study investigates whether immune responses to BNT162b2 vaccine differ in subjects with and without prior SARS-CoV-2 infection

The rollout of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was expected to achieve population-level immunity preventing reinfection, and thus an eventual end to the pandemic of coronavirus disease 2019 (COVID-19). However, the emergence of variants that demonstrate resistance to neutralization by antibodies to the ancestral virus or earlier variants threatens …

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Multiple sclerosis may be caused by infection with the Epstein-Barr virus

Multiple sclerosis may be caused by infection with the Epstein-Barr virus

Multiple sclerosis (MS), a progressive disease that affects 2.8 million people worldwide and for which there is no definitive cure, is likely caused by infection with the Epstein-Barr virus (EBV), according to a study led by Harvard T.H. Chan School of Public Health researchers. Their findings were published online in Science on January 13, 2022. …

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Maternal COVID-19 infection increases risks of preterm birth, low birth weight and stillbirth

Maternal COVID-19 infection increases risks of preterm birth, low birth weight and stillbirth

Creative rendition of SARS-CoV-2 particles (not to scale). Credit: National Institute of Allergy and Infectious Diseases, NIH People who contracted COVID-19 while pregnant were more likely to have poor birth outcomes including preterm birth, small for gestational age, low birth weight, and stillbirth. The poor outcomes of preterm birth and stillbirth were observed primarily with …

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Study: Plasma SARS-CoV-2 RNA levels as a biomarker of lower respiratory tract SARS-CoV-2 infection in critically ill patients with COVID-19. Image Credit: CROCOTHERY/Shutterstock

Plasma SARS-CoV-2 viral RNA as a valuable biomarker for SARS-CoV-2 infection in the lungs

In a recent study posted to the medRxiv* preprint server, researchers evaluated plasma and lower respiratory tract (LRT) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA (vRNA) levels in longitudinal samples collected simultaneously from mechanically ventilated coronavirus disease 2019 (COVID-19) patients and analyzed their connections and relationships with clinical outcomes. Study: Plasma SARS-CoV-2 …

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Common cold coronaviruses hinder antibody immune response to SARS-CoV-2 infection

Common cold coronaviruses hinder antibody immune response to SARS-CoV-2 infection

Maureen McGargill, Ph.D., Department of Immunology, and graduate student Chun-Yang Lin. Credit: St. Jude Children’s Research Hospital Prior infection with coronaviruses that cause the common cold impedes the antibody immune response against SARS-CoV-2, the coronavirus responsible for COVID-19. The results from St. Jude Children’s Research Hospital appeared in print today in the journal Cell Host …

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Study: SARS-CoV-2 Causes a Significant Stress Response Mediated by Small RNAs in the Blood of COVID-19 Patient. Image Credit: creativeneko/Shutterstock

Study finds SARS-CoV-2 infection caused significant changes in the levels of stress associated small RNAs

The coronavirus disease 2019 (COVID-19) pandemic has been caused by a highly infectious RNA virus, namely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This ongoing pandemic has immensely affected the global economy and healthcare system. SARS-CoV-2 symptoms could be mild, moderate, severe, or critical. Study: SARS-CoV-2 Causes a Significant Stress Response Mediated …

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BinaxNOW test catches COVID infection in many people, study shows

BinaxNOW test catches COVID infection in many people, study shows

(HealthDay)—Countering earlier concerns, a real-world study finds that a widely used at-home coronavirus test called BinaxNOW is as effective at detecting Omicron as other COVID-19 variants. The study of Abbot’s rapid antigen test included more than 700 people who visited a walk-up testing site in San Francisco. The test detected 65% of infections caught by …

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