drug

Study paves the way to a new drug design concept

Study paves the way to a new drug design concept

Hydrogen peroxide reacts with copper to produce hydroxyl radicals with strong antibacterial properties. However, this requires high copper concentrations because two copper atoms have to come close together, which occurs by chance. Now, scientists at Tokyo University of Science, Japan, engineered a long polymer with copper-containing side units that create regions with locally high copper …

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FDA's accelerated drug approval process plagued by missing efficacy data and questionable evidence

FDA’s accelerated drug approval process plagued by missing efficacy data and questionable evidence

Since the US Food and Drug Administration (FDA) established its accelerated approval pathway for drugs in 1992, nearly half (112) of the 253 drugs authorized have not been confirmed as clinically effective, an investigation by The BMJ has found. Elisabeth Mahase, clinical reporter at The BMJ, carried out an in depth analysis of FDA data …

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Schematic workflow of SARS-CoV-2 infection modelling. Publicly available COVID-19 datasets are collated into two subsets. Data on the point-to-point signalling pathway interactions of the virus with the host cell, and of the host cell in response to infection, are used to build a network model. Data from experiments showing how the overall behaviour of the infected cell changes under perturbations, such as a potential treatment, are used as a testing dataset to validate the model. The readouts of the model are compared to the testing dataset and the model is refined iteratively until it reproduces all the experimentally observed behaviours. We then screen the effects of potential drug treatments, either singly or in combination, on the model, to find the best predicted therapies for early and late stage severe COVID-19.

In-silico prediction of effective drug combinations for the treatment of SARS-CoV-2 infection

Coronavirus disease 2019 (COVID-19) is a complex disease with a wide range of symptoms, ranging from asymptomatic to very severe. Even though a majority of the people infected with this disease show mild symptoms, the Centers for Disease Control and Prevention (CDC) has reported that in the USA alone, 4.9% of COVID-19 patients required hospitalization, …

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Drug that slows progression of ALS may provide the same benefit for people with Alzheimer's disease

Drug that slows progression of ALS may provide the same benefit for people with Alzheimer’s disease

Credit: Unsplash/CC0 Public Domain Riluzole, a drug that has been used for more than 20 years to slow the progression of ALS, commonly known as Lou Gehrig’s disease, was shown in a pilot phase 2 study to slow brain metabolic decline and have a positive effect on cognitive performance versus placebo in people with mild …

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Genetic variant linked to hearing loss in children treated with common chemotherapy drug

Genetic variant linked to hearing loss in children treated with common chemotherapy drug

Amit Bhavsar, Canada Research Chair in Functional Genomic Medicine, led a U of A team that confirmed that children with the genetic variant TCERG1L have three times the risk of hearing loss due to cisplatin treatment compared with those who don’t have the variant. Credit: William Au A University of Alberta research lab has helped …

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Facing headwinds on new Alzheimer’s drug, Biogen launches controversial campaign

Facing headwinds on new Alzheimer’s drug, Biogen launches controversial campaign

Do you sometimes lose your train of thought or feel a bit more anxious than is typical for you? Those are two of the six questions in a quiz on a website co-sponsored by the makers of Aduhelm, a controversial new Alzheimer’s drug. But even when all responses to the frequency of those experiences are …

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Biogen calls criticism of Alzheimer's drug 'misinformation'

Biogen calls criticism of Alzheimer’s drug ‘misinformation’

Credit: CC0 Public Domain Biogen Inc. fought back against criticism of the unusual circumstances that led to the U.S. approval of its Alzheimer’s drug Aduhelm, saying in an open letter it has been the subject of “extensive misinformation and misunderstanding.” Aduhelm, approved in June, is controversial because it hasn’t been shown to slow cognitive decline. …

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A major ivermectin study has been withdrawn, so what now for the controversial drug?

A major ivermectin study has been withdrawn, so what now for the controversial drug?

Credit: www.shutterstock.com Ivermectin, an existing drug against parasites including head lice, has had a checkered history when it comes to treating COVID-19. The bulk of studies so far show there’s not enough evidence ivermectin is useful in treating or preventing COVID-19, either alone or with antibiotics or supplements. Yet interest in the drug remains, on …

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Smart combination therapy for liver cancer tackles drug resistance

Smart combination therapy for liver cancer tackles drug resistance

Credit: CC0 Public Domain Liver cancer is one of the most common cancer types worldwide and is especially common in China. A collaborative effort between researchers at the Netherlands Cancer Institute and Shanghai using CRISPR/Cas has led to the discovery that insensitivity to a liver cancer drug can be prevented if it is given in …

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Existing drug is shown to inhibit SARS-CoV-2 virus

Existing drug is shown to inhibit SARS-CoV-2 virus

Creative rendition of SARS-CoV-2 particles (not to scale). Credit: National Institute of Allergy and Infectious Diseases, NIH A new University of Chicago study has found that the drug masitinib may be effective in treating COVID-19. The drug, which has undergone several clinical trials for human conditions but has not yet received approval to treat humans, …

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