disease

Study: Safety and Immunogenicity of an Inactivated Recombinant Newcastle Disease Virus Vaccine Expressing SARS-CoV-2 Spike: Interim Results of a Randomised, Placebo-Controlled, Phase 1/2 Trial. Image Credit: creativeneko/ Shutterstock

Inactivated egg-based Newcastle disease virus vaccine expressing SARS-CoV-2 spike protein

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus is the causal agent of the coronavirus disease-2019 (COVID-19) pandemic and has already claimed more than 4.73 million lives worldwide. Vaccination programs have begun in many countries, but low- and middle-income countries (LMICs) are still lacking in the availability of vaccine doses. Study: Safety and Immunogenicity of …

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Chronic obstructive pulmonary disease brought on by tobacco

Chronic obstructive pulmonary disease brought on by tobacco

Credit: CC0 Public Domain Chronic obstructive pulmonary disease (COPD) refers to a progressive group of lung diseases, including chronic bronchitis and emphysema, that make it hard to breathe. Millions of people around the globe die each year because of COPD, and nearly 16 million people in the U.S. have a form of the disease. The …

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Discovery points toward a new strategy for treating Parkinson's disease

Discovery points toward a new strategy for treating Parkinson’s disease

University of Utah Health scientists have identified a molecule that slows cells’ production of alpha-synuclein, a protein that forms toxic aggregates in the brains of people with Parkinson’s disease. Its discovery points toward a new strategy for treating the disease and potentially stopping its progression. Researchers led by Associate Professor of Neurology Daniel Scoles, Ph.D., …

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Study investigates if music can improve memory in people with Alzheimer's disease

Study investigates if music can improve memory in people with Alzheimer’s disease

The main goal of the study, named “The Mozart Effect and memory in patients with cognitive impairment (MEM-COG)”, is to investigate whether music can be used to facilitate or enhance learning in those with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD). It will also look at which aspects of music are key in …

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Nasal drugs show promise for slowing Parkinson's disease progression in lab study

Nasal drugs show promise for slowing Parkinson’s disease progression in lab study

Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Potential new treatments for Parkinson’s disease developed by researchers at Rush University Medical Center have shown success in slowing progression of the disease in mice. In a study published in Nature Communications, Rush researchers found …

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BUSM assistant professor awarded $2.1 million for peripheral artery disease research

BUSM assistant professor awarded $2.1 million for peripheral artery disease research

Peripheral artery disease (PAD) is a major cause of limb loss. It is estimated that PAD affects between 8.5 and 12 million Americans, with a prevalence that has increased by about 25 percent over the preceding decade. Vijaya B. Kolachalama, PhD, FAHA, assistant professor of medicine at Boston University School of Medicine (BUSM), and his …

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DNA modifications could be used to determine the progression of severe liver disease

DNA modifications could be used to determine the progression of severe liver disease

A double stranded DNA fragment. Credit: Vcpmartin/Wikimedia/ CC BY-SA 4.0 Findings of a national study led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, identify potential biomarkers that might eventually be used to diagnose progressive stages of liver disease. Researchers identified differences in DNA methylation (DNAm) that accurately predicted different …

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More than 40% of adults with no known heart disease had fatty deposits in heart arteries

More than 40% of adults with no known heart disease had fatty deposits in heart arteries

Credit: Pixabay/CC0 Public Domain More than 40% of adults ages 50 to 64 years in Sweden without known heart disease were found to have some degree of atherosclerosis, according to a new study published today in the American Heart Association’s flagship journal Circulation. Atherosclerosis, or the buildup of fatty deposits in blood vessels that supply …

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Study: Humoral immune responses against seasonal coronaviruses predict efficiency of SARS-CoV-2 spike targeting, FcγR activation, and corresponding COVID-19 disease severity. Image Credit: NIAID

The influence of prior seasonal coronavirus infection on disease severity in COVID-19

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a novel virus that causes coronavirus disease (COVID-19). Early detection of Immunoglobulin G (IgG) against SARS-CoV-2 spike proteins in COVID-19 patients has been reported, which is not typically observed in other infections. It has been suggested that the early response may be the result of prior exposure to …

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