Tag Archives: combination

Combination of chemo and diabetes drugs shows potential for treating Ewing sarcoma

Stephen T. Wong, Ph.D., Associate Director, Cores, Biostatistics and BioinformaticsHouston Methodist Cancer Center. Credit: Houston Methodist Ewing sarcoma, an aggressive tumor that commonly affects bones in adolescents and young adults, is diagnosed in about 225 American children and teens every year, accounting for about 1 percent of pediatric cancers. Although …

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Novel combination therapy has similar response rates to chemotherapy for high-risk luminal B breast cancer

Neoadjuvant treatment with the CDK4/6 inhibitor ribociclib (Kisqali) and the aromatase inhibitor letrozole (Femara) produced response rates similar to multi-agent chemotherapy in patients with high-risk luminal B breast cancer, according to results from the SOLTI-1402/CORALLEEN trial presented at the San Antonio Breast Cancer Symposium, held Dec. 10-14. Data from this …

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Adding tucatinib to drug combination extends survival for advanced HER2+ breast cancer patients

Credit: CC0 Public Domain Researchers from The University of Texas MD Anderson Cancer Center today reported study results showing the addition of tucatinib to capecitabine (Xeloda) and trastuzumab (Herceptin) significantly improved progression-free survival (PFS) and overall survival (OS) in patients with advanced HER2-positive breast cancer, with and without brain metastasis …

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Combination therapy more effective than chemotherapy alone for many newly diagnosed leukemia patients

Credit: CC0 Public Domain A multi-institutional, Phase II study led by The University of Texas MD Anderson Cancer Center showed that pairing standard chemotherapy azacitidine (AZA) with a drug called enasidenib (ENA) measurably boosts complete remission in patients newly diagnosed with a specific form of acute myeloid leukemia (AML). Findings …

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When your microbiome and your genome aren’t a good combination

We collected fecal samples from 82 patients with rheumatoid arthritis (RA) and 42 healthy controls. We conducted a shotgun sequencing-based metagenome-wide association study, which consisted of three major bioinformatic analytic techniques for case-control comparisons: phylogenetic analysis, functional gene analysis, and pathway analysis. To assess the taxonomic relative abundance data, we …

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