Clinical

Researchers find gaps in clinical trial data sharing

Researchers find gaps in clinical trial data sharing

Credit: CC0 Public Domain Access to clinical-trial data helps doctors make informed prescribing decisions and promotes good science, but a new study co-authored by Yale researchers reveals that few pharmaceutical companies are fully transparent about the data behind the products they develop. The study also shows that large companies are far more transparent than smaller …

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FDA allows drugs without proven clinical benefit to languish for years on accelerated pathway

FDA allows drugs without proven clinical benefit to languish for years on accelerated pathway

Credit: CC0 Public Domain Since the US Food and Drug Administration (FDA) established its accelerated approval pathway for drugs in 1992, nearly half (112) of the 253 drugs authorised have not been confirmed as clinically effective, an investigation by The BMJ has found. Elisabeth Mahase, clinical reporter at The BMJ, carried out an in depth …

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Clinical trial gives hope to sufferers of rare genetic liver disease

Clinical trial gives hope to sufferers of rare genetic liver disease

Credit: Magic mine, Shutterstock Preliminary results of a clinical trial for Crigler-Najjar syndrome point to gene therapy as a potential alternative treatment for this life-threatening liver disease. A new clinical trial is offering hope for sufferers of Crigler-Najjar syndrome, a deadly and currently incurable genetic disorder that affects around one in a million newborn babies …

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Comprehensive clinical sequencing opens door to the promise of precision medicine

Comprehensive clinical sequencing opens door to the promise of precision medicine

Credit: Pixabay/CC0 Public Domain St. Jude Children’s Research Hospital investigators have demonstrated that comprehensive genomic sequencing of all pediatric cancer patients is feasible and essential to capitalize on the lifesaving potential of precision medicine. Results from the St. Jude Genomes for Kids study appear online today in the journal Cancer Discovery. Whole genome and whole …

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Clinical trials during a pandemic – lessons from COVID-19

Clinical trials during a pandemic – lessons from COVID-19

Clinical trials are vital and ongoing, particularly during the current pandemic. However, the risk from variants remains a concern. A number of clinical pathologists from Cerba Laboratory recently presented some approaches on how to manage SARS CoV 2 variants during the clinical trial process. Dr. Benedicte Roquebert is based in the microbiology department of Cerba …

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Study: Clinical outcomes in vaccinated individuals hospitalized with Delta variant of SARS-CoV-2. Image Credit: joshimerbin / Shutterstock

Study examines clinical outcomes in vaccinated individuals hospitalized with SARS-CoV-2 Delta variant

The rapid development and rolling out of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been considered as a huge step forward towards containing the ongoing coronavirus disease 2019 (COVID-19) pandemic. However, the continual emergence of SARS-CoV-2 variants across the world has made the scientific community skeptical towards the effectiveness of the available …

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Review: SARS-CoV-2 Clinical Outcome in Domestic and Wild Cats: A Systematic Review. Image Credit: Ekachai Prasertkaew / Shutterstock

Review details clinical signs of SARS-CoV-2 infection in domestic and wild cats

Coronaviruses are RNA viruses that infect both animals as well as humans. The current coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has claimed more than 4 million lives globally. This virus has been described as a zoonotic virus and might have originated from bats with an unknown intermediate host. …

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Surgical predictors of clinical outcome six years following revision ACL reconstruction

Orthopedic surgeons know that knee surgeries that require revisions have inferior outcomes compared with primary surgeries but until now, the reason for this was unknown. Today a team of orthopedic physicians reports that opting for a transtibial surgical approach and choosing an inference screw for femoral and tibial fixation will improve the patient’s odds of …

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Lack of consideration of sex and gender in COVID-19 clinical studies

Lack of consideration of sex and gender in COVID-19 clinical studies

“Most clinical studies on coronavirus and the associated disease ignore the fact that women and men are affected differently,” says study author Dr. Sabine Oertelt-Prigione from Bielefeld University. Credit: Bielefeld University Although COVID-19 affects men and women differently, the large majority of current clinical studies of SARS-CoV-2 and COVID-19 makes no mention of sex/gender. Indeed, only …

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What underlies inconsistent clinical trials results for COVID-19 drugs?

What underlies inconsistent clinical trials results for COVID-19 drugs?

Schematic illustration of sample size calculation process. Credit: Shoya Iwanami, CC0 (creativecommons.org/publicdomain/zero/1.0/) A new modeling study suggests that significant variation in virus dynamics from person to person may be a contributing factor to inconsistent findings reported in clinical trials for antiviral COVID-19 drugs. Recruiting trial participants shortly after symptoms begin could reduce the number of …

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