ALS

Repurposed ALS drug could slow gradual brain cell loss in Niemann-Pick disease type C1

Repurposed ALS drug could slow gradual brain cell loss in Niemann-Pick disease type C1

Riluzole, a drug approved to treat amyotrophic lateral sclerosis (ALS), a disease affecting nerve cells controlling movement, could slow the gradual loss of a particular brain cell that occurs in Niemann-Pick disease type C1 (NPC1), a rare genetic disorder affecting children and adolescents, suggests a study in mice by scientists at the National Institutes of …

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ALS also causes retinal alterations, study reveals

ALS also causes retinal alterations, study reveals

Amyotrophic lateral sclerosis (ALS), characterized by harm to brain neurons and to the spinal cord, also affects the tissue of the retina, according to a study headed up by Universidad Complutense de Madrid (UCM). The research, published in Neural Regeneration Research, indicates that patients with ALS may suffer changes in the microglial cells, responsible for …

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Study reveals the role of SPOP protein in an inherited form of ALS

Study reveals the role of SPOP protein in an inherited form of ALS

The damaging effects of toxic proteins created in one inherited form of amyotrophic lateral sclerosis (ALS) are mediated by a protein called SPOP, according to a study published in the Proceedings of the National Academy of the Sciences (PNAS). Reducing the abundance of SPOP or inhibiting its activity with a small molecule could protect neurons …

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Does a lifetime of vigorous exercise increase the risk of developing ALS?

Does a lifetime of vigorous exercise increase the risk of developing ALS?

An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia There is debate over whether vigorous physical activity is a risk factor for amyotrophic lateral sclerosis (ALS). A new study suggests it depends on whether …

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Blood lipoprotein levels linked to future risk of ALS

Blood lipoprotein levels linked to future risk of ALS

An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia Some blood lipid biomarkers linked to cardiovascular disease risk are also associated with a lower risk of amyotrophic lateral sclerosis (ALS) suggest the findings of …

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Researchers identify a cellular defect common to familial and sporadic forms of ALS

Researchers identify a cellular defect common to familial and sporadic forms of ALS

An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal degenerative disease affecting the nerve cells in the brain and spinal cord responsible for controlling …

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Drug that slows progression of ALS may provide the same benefit for people with Alzheimer's disease

Drug that slows progression of ALS may provide the same benefit for people with Alzheimer’s disease

Credit: Unsplash/CC0 Public Domain Riluzole, a drug that has been used for more than 20 years to slow the progression of ALS, commonly known as Lou Gehrig’s disease, was shown in a pilot phase 2 study to slow brain metabolic decline and have a positive effect on cognitive performance versus placebo in people with mild …

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Research shines light on how cells recover from threats, may lead to new insights into Alzheimer's and ALS

Research shines light on how cells recover from threats, may lead to new insights into Alzheimer’s and ALS

Ubiquitin tags in cells serve different functions depending on stress conditions. Credit: Michael Hughes, CC BY-ND Our bodies contain a special protein tag that plays a role in how cells recover from specific threats to their survival, according to new research I co-authored. Understanding how this process works may be key to future treatments for …

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Researchers identify new gene that may increase risk of ALS

Researchers identify new gene that may increase risk of ALS

An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia Researchers have identified a new gene that may increase a person’s risk of developing ALS (Amyotrophic Lateral Sclerosis), according to a new study published in …

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Scientists discover a new genetic form of ALS in children

Scientists discover a new genetic form of ALS in children

NIH researchers discovered a new form of ALS that begins in childhood. The study linked the disease to a gene called SPLTC1. As part of the study, NIH senior scientist Carsten Bonnemann, M.D., (right) examined Claudia Digregorio (left), a patient from the Apulia region of Italy. Credit: NIH/NINDS. In a study of 11 medical-mystery patients, …

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