New simple plasmonic optical fiber biosensing platform for detecting estrogenic endocrine disruptors

New simple plasmonic optical fiber biosensing platform for detecting estrogenic endocrine disruptors

New simple plasmonic optical fiber biosensing platform for detecting estrogenic

Developing the advanced and powerful detection techniques to characterize as many endocrine disruptors as possible with ultra-sensitivity in the environment is still challenging, however highly demanded. Environmental estrogens (EEs), as typical endocrine disruptors, have been listed as one of the global environmental issues to be addressed through international collaboration by the United Nations. They are structurally diverse compounds that can interact with nuclear estrogen receptors and pose significant risks to ecological and human health.

In a new paper published in Light Science & Application, a team of photonics and environmental scientists, led by Prof. Tuan Guo from Jinan University and Dr. Xiaohong Zhou from Tsinghua University, developed a simple-to-implement plasmonic optical fiber biosensing platform for ultrasensitive detection of estrogenic endocrine disruptors. The platform is based on a gold-coated highly tilted fiber Bragg grating, which excites high-density narrow cladding mode spectral combs overlapping with the broader absorption of the surface plasmon for high accuracy interrogation, hence enabling the ultrasensitive monitoring of refractive index changes at the fiber surface. Through the use of estrogen receptors as the model, they design an estradiol-streptavidin conjugate with the assistance of molecular dynamics, converting the specific recognition of environmental estrogens by estrogen receptor into surface-based affinity bioassay for protein. The ultrasensitive platform with conjugate-induced amplification biosensing approach enables the subsequent detection for EEs down to 1.5 ng l-1 estradiol equivalent concentration. It is the lowest limit of detection for any estrogen receptors-based detection reported to date.

Moreover, the compact size, flexible shape, and remote operation capability of in-fiber plasmonic biosensor open the way for detecting other endocrine disruptors with ultrahigh sensitivity and in various hard-to-reach spaces, thereby having the potential to revolutionize environment and health monitoring. For example, the biosensor is able to perform for the in-field continuous detection of endocrine disruptors, meeting the highly desired demand for the timely monitoring of environmental status. By integrating such fiber biosensor with a hypodermic needle on the other hand would allow similar measurements, as portable on-site and in-field analysis in health monitoring, even in vivo.


Journal reference:

Liu, L., et al. (2021) Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs. Light: Science & Applications.